Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TAPI-1 trifluoroacetat 是一种 ADAM17/TACE 抑制剂,可阻断细胞因子受体的脱落。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,440 | 待询 | ||
2 mg | ¥ 2,592 | 待询 | ||
5 mg | ¥ 5,736 | 待询 |
产品描述 | TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors. |
体外活性 | TAPI-1 prevents unstimulated and PMA-induced release of the soluble forms of TNF-alpha, p60 TNFR, and IL-6R from the monocytic cell line, THP-1, and from human peripheral blood monocytes. TAPI also inhibits LPS-induced shedding of the p60 TNFR and TNF-alpha from monocytes. TAPI-1 inhibits TACE-dependent constitutive release of co-transfected APP(695). TAPI-1 attenuates Ang II-induced EGFR transactivation and cell proliferation in human HSC line LI90. TAPI-1 with the EGFR inhibitor AG1478 exhibits deactivated AREG/EGFR/ERK signaling pathway and reduces pro-inflammatory cytokines release in pSS salivary gland-derived epithelial cells. |
分子量 | 613.62 |
分子式 | C28H38F3N5O7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mM
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.6297 mL | 8.1484 mL | 16.2967 mL | 40.7418 mL |
5 mM | 0.3259 mL | 1.6297 mL | 3.2593 mL | 8.1484 mL | |
10 mM | 0.163 mL | 0.8148 mL | 1.6297 mL | 4.0742 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
TAPI-1 trifluoroacetate (163847-77-6(free base)) Proteases/Proteasome MMP TAPI1 trifluoroacetate (171235715(free base)) TAPI 1 trifluoroacetate (171235 71 5(free base)) Inhibitor inhibitor inhibit